Spatially Controlled Templated Hydrogels for Orthopedic Interfacial Tissue Regeneration,ACS Macro Letters

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Spatially Controlled Templated Hydrogels for Orthopedic Interfacial Tissue Regeneration
ACS Macro Letters ( IF 5.1 ) Pub Date : 2020-11-16 , DOI: 10.1021/acsmacrolett.0c00712
Michael T. Frassica ₁ , Connor J. Demott ₁ , Esteban M. Ramirez ₁ , Melissa A. Grunlan _{1,

2,

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Affiliation

Scaffolds that recapitulate the spatial complexity of orthopedic interfacial tissues are essential to their regeneration. This requires a method to readily and flexibly produce scaffolds with spatial control over physical and chemical properties, without resulting in hard interfaces. Herein, we produced hydrogel scaffolds with spatially tunable arrangements and chemistries (SSTACs). Using solvent-induced phase separation/fused salt templating (SIPS/salt), scaffold elements are initially prepared with a tunable pore size and with one or more UV-reactive macromers. After trimming to the desired dimensions, these are physically configured and fused together to form the SSTACs. Using this method, three SSTAC designs were prepared, including one that mimicked the osteochondral interface. Bright-field/fluorescent microscopy revealed spatial control of pore size and chemical composition across a relatively smooth and integrated interface, regardless of layer composition. An interface formed by a SSTAC was determined to withstand a similar shear force to an analogous scaffold with no interface.

中文翻译：

用于骨科界面组织再生的空间控制模板化水凝胶

概述骨科界面组织空间复杂性的支架对其再生至关重要。这需要一种容易且灵活地制造具有对物理和化学性质进行空间控制的支架而不会导致硬界面的方法。本文中，我们生产了具有空间可调的排列和化学结构（SSTAC）的水凝胶支架。使用溶剂诱导的相分离/熔融盐模板（SIPS /盐），首先制备具有可调孔径和一种或多种紫外线反应性大分子单体的支架元件。修整到所需的尺寸后，将它们物理配置并融合在一起以形成SSTAC。使用这种方法，准备了三种SSTAC设计，包括一种模仿骨软骨界面的设计。明场/荧光显微镜揭示了相对大小和化学组成界面的孔径和化学成分的空间控制，而与层组成无关。确定由SSTAC形成的界面要承受与没有界面的类似支架相似的剪切力。

更新日期：2020-12-15

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