当前位置：
X-MOL 学术
›
ACS Biomater. Sci. Eng.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Sequential Release Platform of Heparin and Urokinase with Dual Physical (NIR-II and Bubbles) Assistance for Deep Venous Thrombosis
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-11-17 , DOI: 10.1021/acsbiomaterials.0c01372 Zhiwei Zhong 1 , Cuifu Fang 1 , Shasha He 2 , Teng Zhang 1 , Shichen Liu 1 , Yini Zhang 3 , Qingqing Wang 3 , Xingwei Ding 4 , Weimin Zhou 1 , Xiaolei Wang 3, 4
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-11-17 , DOI: 10.1021/acsbiomaterials.0c01372 Zhiwei Zhong 1 , Cuifu Fang 1 , Shasha He 2 , Teng Zhang 1 , Shichen Liu 1 , Yini Zhang 3 , Qingqing Wang 3 , Xingwei Ding 4 , Weimin Zhou 1 , Xiaolei Wang 3, 4
Affiliation
|
Disability and even death from acute thrombosis remain a grave menace to public health. At present, the traditional drugs represented by urokinase (UK) in clinical thrombolysis can cause side effects of bleeding when the dosage is excess. Therefore, a more effective and safer method of thrombolysis is urgently needed. In this paper, a multifunctional dual-drug sequential release thrombolysis platform (UK-UH@PDA@HMSNs) consisting of polydopamine (PDA)-modified hollow mesoporous silicon (HMSNs) loading with UK and unfractionated heparin (UH) was constructed with a double physical assistance (NIR-II and bubbles). With the aid of near infrared-II (NIR-II, 1064 nm, 1.0 W cm–2) laser, the photothermal effect of PDA could be motivated to facilitate the UH release, thereby accelerating the dissolution of thrombus. Afterward, the local hyperthermia effect could expedite the phase transition of l-menthol in HMSNs to generate bubbles to promote the release of UK, thereby realizing the sequential release of two thrombolytic drugs. Importantly, this method deftly conquered the inherent obstacle that UK and UH cannot be combined directly. In vivo and in vitro experiments proved that the thrombolytic efficiency of UK-UH@PDA@HMSNs stimulated by NIR-II was nearly 3 times than that of UK alone. Collectively, the proposed dual physical assistance and sequential dual-drug delivery system significantly improved the efficiency of thrombolysis under the premise of limiting drug doses; the risk of death from intracranial hemorrhage thus could be decreased radically.
中文翻译：
具有双重物理（NIR-II和气泡）辅助功能的肝素和尿激酶顺序释放平台可用于深静脉血栓形成
残疾甚至因急性血栓形成而死亡仍然是严重危害公共卫生的事情。目前，在临床溶栓治疗中以尿激酶（UK）为代表的传统药物在过量使用时会引起出血的副作用。因此，迫切需要一种更有效，更安全的溶栓方法。本文构建了一个多功能的双重药物顺序释放溶栓平台（UK-UH @ PDA @ HMSNs），该平台由聚多巴胺（PDA）修饰的中孔介孔硅（HMSNs）和UK以及普通肝素（UH）组成。身体上的帮助（NIR-II和泡泡）。借助近红外II（NIR-II，1064 nm，1.0 W cm –2）激光，可以激发PDA的光热效应以促进UH释放，从而加速血栓的溶解。此后，局部热疗作用可加速HMSNs中1-薄荷醇的相变，产生气泡以促进UK的释放，从而实现两种溶栓药的顺序释放。重要的是，这种方法巧妙地克服了英国和UH无法直接合并的固有障碍。体内和体外实验证明，NIR-II刺激UK-UH @ PDA @ HMSNs的溶栓效率是仅UK的近3倍。总体而言，在限制药物剂量的前提下，拟议的双重身体辅助和顺序双重药物输送系统显着提高了溶栓的效率。因此可以从根本上降低颅内出血致死的风险。
更新日期：2020-11-17
中文翻译：
具有双重物理（NIR-II和气泡）辅助功能的肝素和尿激酶顺序释放平台可用于深静脉血栓形成
残疾甚至因急性血栓形成而死亡仍然是严重危害公共卫生的事情。目前，在临床溶栓治疗中以尿激酶（UK）为代表的传统药物在过量使用时会引起出血的副作用。因此，迫切需要一种更有效，更安全的溶栓方法。本文构建了一个多功能的双重药物顺序释放溶栓平台（UK-UH @ PDA @ HMSNs），该平台由聚多巴胺（PDA）修饰的中孔介孔硅（HMSNs）和UK以及普通肝素（UH）组成。身体上的帮助（NIR-II和泡泡）。借助近红外II（NIR-II，1064 nm，1.0 W cm –2）激光，可以激发PDA的光热效应以促进UH释放，从而加速血栓的溶解。此后，局部热疗作用可加速HMSNs中1-薄荷醇的相变，产生气泡以促进UK的释放，从而实现两种溶栓药的顺序释放。重要的是，这种方法巧妙地克服了英国和UH无法直接合并的固有障碍。体内和体外实验证明，NIR-II刺激UK-UH @ PDA @ HMSNs的溶栓效率是仅UK的近3倍。总体而言，在限制药物剂量的前提下，拟议的双重身体辅助和顺序双重药物输送系统显着提高了溶栓的效率。因此可以从根本上降低颅内出血致死的风险。
京公网安备 11010802027423号