The advent of organoid technology has enabled scientists and clinicians to utilize cells from primary tissues or pluripotent stem cells (PSCs) to grow self-organizing tissue systems, thus attaining cellular diversity, spatial organization, and functionality as found within digestive tracts. The development of human gastrointestinal (GI) and hepato-biliary-pancreatic organoids as an in-a-dish model present novel opportunities to study humanistic mechanisms of organogenesis, regeneration and pathogenesis. Herein, we review the recent portfolios of primary tissue-derived and PSC-derived organoids in the digestive systems. We also discuss the promise and challenges in disease modeling and drug development applications for digestive disorders.

类器官技术的出现使科学家和临床医生能够利用来自原代组织或多能干细胞 (PSC) 的细胞来培养自组织组织系统，从而获得消化道内的细胞多样性、空间组织和功能。人类胃肠道 (GI) 和肝胆胰类器官作为盘内模型的发展为研究器官发生、再生和发病机制的人文机制提供了新的机会。在此，我们回顾了消化系统中原发性组织衍生和 PSC 衍生类器官的最新组合。我们还讨论了疾病建模和消化系统疾病药物开发应用的前景和挑战。