ABSTRACT

The wounds caused by either burning or trauma are recognised potentially dangerous. Hydrogels are perceived as promising materials in wounds care applications. In the first step, various compounds were fabricated to obtain the optimal composition and then characterised using several techniques, including a water vapour passage test, antibacterial test, scanning electron microscopy, water absorption, tensile strength, biodegradability, and Fourier transform infrared spectroscopy. Next, silver nanoparticles (AgNPs) plus sildenafil citrate as a well-known angiogenesis stimulant were added to the compound. The prepared wound dressings with different compounds were applied to three Wistar rat groups. Haematoxylin and eosin, and silver staining methods were used. The results revealed the optimised sample and the sample possessing the AgNPs outperformed the others in antibacterial activity. The angiogenesis was significantly triggered by the sildenafil citrate-treated group, and the better recovery was observed for rats treated with the optimised sample encompassing AgNPs and sildenafil citrate.

摘要

由烧伤或外伤引起的伤口被认为具有潜在危险。水凝胶被认为是伤口护理应用中很有前途的材料。在第一步中，制备各种化合物以获得最佳组成，然后使用多种技术进行表征，包括水蒸气通过测试、抗菌测试、扫描电子显微镜、吸水率、拉伸强度、生物降解性和傅里叶变换红外光谱。接下来，将银纳米颗粒 (AgNPs) 和柠檬酸西地那非作为众所周知的血管生成兴奋剂添加到化合物中。将制备的具有不同化合物的伤口敷料应用于三个 Wistar 大鼠组。使用苏木精和伊红和银染方法。结果显示优化的样品和具有AgNPs的样品在抗菌活性方面优于其他样品。枸橼酸西地那非治疗组显着触发了血管生成，并且观察到用包含AgNPs和枸橼酸西地那非的优化样品治疗的大鼠具有更好的恢复。