Abstract

Two new azaphilone pigments, talaralbols A and B (3 and 7), along with five known azaphilone metabolites (1, 2, and 4–6), were isolated from the culture of Talaromyces albobiverticillius associated with the isopod Armadillidium vulgare. Their structures were elucidated by a combination of 1 D and 2 D NMR data, ECD calculations, chemical transformations, and NMR data analogy with model compounds. Talaralbol A (3) showed a moderate inhibition on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells with the inhibitory rate being 31.0% at the concentration of 10 μM.

摘要

两个新的azaphilone色素，talaralbols A和B（3和7）中，用5种已知azaphilone代谢物（沿1，2，和4 - 6），从所述的培养物中分离的Talaromyces albobiverticillius与等足相关的鼠妇。通过将1 D和2 D NMR数据，ECD计算，化学转化以及与模型化合物类似的NMR数据相结合，阐明了它们的结构。Talaralbol A（3）显示出在脂多糖适度抑制（LPS）诱导的一氧化氮（NO）在RAW264.7细胞与抑制率在10的浓度为31.0％的生产 μM.