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Potential Mobilization of mcr-10 by an Integrative Mobile Element via Site-Specific Recombination in Cronobacter sakazakii
Antimicrobial Agents and Chemotherapy ( IF 4.1 ) Pub Date : 2021-01-20 , DOI: 10.1128/aac.01717-20
Jing Yang 1, 2, 3 , Lina Liu 4 , Yu Feng 1, 3, 4 , Da He 1, 3 , Chengcheng Wang 1, 3, 4 , Zhiyong Zong 3, 4, 5, 6
Affiliation  

mcr-10 is a newly identified plasmid-borne colistin resistance gene, but its mobilization mechanism remains unclear. In this study, mcr-10 was found on an IncFIB plasmid carrying virulence genes mrkABCDFJ, iucABCD/iutA, and eitCBAD in a Cronobacter sakazakii isolate. By comparison with closely related plasmids, two recombination sites were identified flanking the genetic element containing mcr-10 and an integrase-encoding gene, suggesting that site-specific recombination mediated by an integrase of an integrative mobile element is a potential mechanism for mobilizing mcr-10.

中文翻译:

阪神克氏杆菌通过位点特异性重组通过整合的移动元件动员mcr-10的潜力。

mcr-10是新近鉴定的质粒携带的大肠粘菌素抗性基因,但其动员机制尚不清楚。在这项研究中,在阪崎肠杆菌分离株中带有毒力基因mrkABCDFJiucABCD / iutAeitCBAD的IncFIB质粒上发现了mcr-10。通过与密切相关的质粒进行比较,确定了两个重组位点,位于包含mcr-10和整合酶编码基因的遗传元件的侧翼,这表明由整合移动元件整合介导的位点特异性重组是动员mcr- 10
更新日期:2021-01-20
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