mcr-10 is a newly identified plasmid-borne colistin resistance gene, but its mobilization mechanism remains unclear. In this study, mcr-10 was found on an IncFIB plasmid carrying virulence genes mrkABCDFJ, iucABCD/iutA, and eitCBAD in a Cronobacter sakazakii isolate. By comparison with closely related plasmids, two recombination sites were identified flanking the genetic element containing mcr-10 and an integrase-encoding gene, suggesting that site-specific recombination mediated by an integrase of an integrative mobile element is a potential mechanism for mobilizing mcr-10.

中文翻译：

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阪神克氏杆菌通过位点特异性重组通过整合的移动元件动员mcr-10的潜力。

mcr-10是新近鉴定的质粒携带的大肠粘菌素抗性基因，但其动员机制尚不清楚。在这项研究中，在阪崎肠杆菌分离株中带有毒力基因mrkABCDFJ，iucABCD / iutA和eitCBAD的IncFIB质粒上发现了mcr-10。通过与密切相关的质粒进行比较，确定了两个重组位点，位于包含mcr-10和整合酶编码基因的遗传元件的侧翼，这表明由整合移动元件整合介导的位点特异性重组是动员mcr- 10。