Characterization of a Plasmid-Encoded Resistance-Nodulation-Division Efflux Pump in Klebsiella pneumoniae and Klebsiella quasipneumoniae from Patients in China,Antimicrobial Agents and Chemotherapy

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Characterization of a Plasmid-Encoded Resistance-Nodulation-Division Efflux Pump in Klebsiella pneumoniae and Klebsiella quasipneumoniae from Patients in China
Antimicrobial Agents and Chemotherapy ( IF 4.1 ) Pub Date : 2021-01-20 , DOI: 10.1128/aac.02075-20
Ruowen He _{1,

2} , Yongqiang Yang _{1,

2,

3} , Yiping Wu _{1,

2} , Lan-Lan Zhong _{1,

2} , Yanxian Yang _{1,

2} , Guanping Chen ₄ , Mingyang Qin ₅ , Xiaoxue Liang ₆ , Mohamed Abd El-Gawad El-Sayed Ahmed _{1,

2,

7} , Minmin Lin ₈ , Bin Yan ₉ , Yong Xia ₁₀ , Min Dai ₁₁ , Hongtao Chen ₁₂ , Guo-Bao Tian _{2,

13,

14}

Affiliation

Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China.
School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, China.
Sun Yat-sen University School of Medicine, Guangzhou, China.
Basic Medical College, Xinxiang Medical University, Xinxiang, China.
School of Laboratory Medicine, Chengdu Medical College, Chengdu, China.
Department of Microbiology and Immunology, Faculty of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Cairo, 6th of October City, Egypt.
Department of Respiratory Medicine, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
Department of Neonatal Surgery, Guangzhou Women and Children's Medical Center, Guangzhou, China.
Department of Clinical Laboratory Medicine, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
School of Laboratory Medicine, Chengdu Medical College, Chengdu, China
Department of Clinical Lab, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, China
Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China.

Two multidrug-resistant (MDR) mcr-1-harboring Klebsiella pneumoniae isolates from patients with urinary tract infections and one MDR Klebsiella quasipneumoniae isolate from a patient with bloodstream infection were identified to carry tmexCD1-toprJ1. The addition of the efflux pump inhibitor reduced the tigecycline MIC against all three isolates by 8- to 16-fold. pKQBSI104-1 was transferred from K. quasipneumoniae to Escherichia coli J53 via conjugation. The tmexCD1-toprJ1-carrying plasmids pKP15ZE495-1 (102,569 bp) and pKQBSI104-1 (121,996 bp) were completely sequenced and analyzed.

更新日期：2021-01-20

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