Chromatin is a highly dynamic structure whose plasticity is achieved through multiple processes including the posttranslational modification of histone tails. Histone modifications function through the recruitment of nonhistone proteins to chromatin and thus have the potential to influence many fundamental biological processes. Here, we focus on the function and regulation of lysine 20 of histone H4 (H4K20) methylation in multiple biological processes including DNA repair, cell cycle regulation and DNA replication. The purpose of this review is to highlight recent studies that elucidate the functions associated with each of the methylation states of H4K20, their modifying enzymes, and their protein readers. Based on our current knowledge of H4K20 methylation, we critically analyze the data supporting these functions and outline questions for future research.

中文翻译：

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组蛋白 4 赖氨酸 20 的甲基化：对该领域状况的批判性分析

染色质是一种高度动态的结构，其可塑性是通过多个过程实现的，包括组蛋白尾部的翻译后修饰。组蛋白修饰通过招募非组蛋白到染色质发挥作用，因此有可能影响许多基本的生物过程。在这里，我们专注于组蛋白 H4 (H4K20) 甲基化赖氨酸 20 在 DNA 修复、细胞周期调控和 DNA 复制等多个生物过程中的功能和调控。这篇综述的目的是强调最近的研究，这些研究阐明了与 H4K20 的每种甲基化状态、它们的修饰酶和它们的蛋白质阅读器相关的功能。根据我们目前对 H4K20 甲基化的了解，