Streptogramins are antibiotics produced by several species of Streptomyces bacteria that are used in both human and veterinary medicine. Group A streptogramins comprise 23-membered macrocyclic polyketide/nonribosomal peptide hybrids for which several innovative fully synthetic routes have been developed. Herein we describe in detail our scalable routes to natural Group A streptogramins and we compare these routes to other reported syntheses.

中文翻译：

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链霉素抗生素的模块化合成

链霉素是由几种链霉菌产生的抗生素，可用于人类和兽医。A 组链霉素包含 23 元大环聚酮化合物/非核糖体肽杂化物，已开发出几种创新的全合成路线。在这里，我们详细描述了我们对天然 A 组链菌素的可扩展路线，并将这些路线与其他报道的合成进行了比较。