Standard treatment–refractory cytomegalovirus encephalitis unmasked by immune reconstitution inflammatory syndrome and successfully treated with virus‐specific hyperimmune globulin,Clinical & Translational Immunology

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Standard treatment–refractory cytomegalovirus encephalitis unmasked by immune reconstitution inflammatory syndrome and successfully treated with virus‐specific hyperimmune globulin
Clinical & Translational Immunology ( IF 4.6 ) Pub Date : 2020-11-17 , DOI: 10.1002/cti2.1201
Natalia Maximova ₁ , Annalisa Marcuzzi ₂ , Irene Del Rizzo ₃ , Davide Zanon ₁ , Alessandra Maestro ₁ , Egidio Barbi _{1,

3} , Roberto Sala ₄

Affiliation

Cytomegalovirus (CMV)‐related encephalitis is a rare but potentially life‐threatening complication of CMV infection in immunocompromised patients. The high mortality rate is associated with deficient immune system reconstitution after hematopoietic stem cell transplant (HSCT) and poor bioavailability of antiviral drugs in cerebrospinal fluid (CSF). CMV‐related central nervous system (CNS) infection may occur with aspecific symptoms, without evidence of either blood viral load or magnetic resonance imaging (MRI) signs of encephalitis.

中文翻译：

标准治疗——免疫重建炎症综合征未掩盖的难治性巨细胞病毒脑炎，并用病毒特异性超免疫球蛋白成功治疗

巨细胞病毒 (CMV) 相关性脑炎是免疫功能低下患者中 CMV 感染的一种罕见但可能危及生命的并发症。高死亡率与造血干细胞移植（HSCT）后免疫系统重建不足和脑脊液（CSF）中抗病毒药物的生物利用度差有关。CMV 相关的中枢神经系统 (CNS) 感染可能出现非特异性症状，没有证据表明血液病毒载量或脑炎的磁共振成像 (MRI) 迹象。

更新日期：2020-11-17

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