A combined multicomponent‐acid catalyzed cyclization reaction as an efficient route to novel tricyclic pyrrolo[2,1‐a]isoquinoline derivatives,Journal of Heterocyclic Chemistry

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A combined multicomponent‐acid catalyzed cyclization reaction as an efficient route to novel tricyclic pyrrolo[2,1‐a]isoquinoline derivatives
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-11-17 , DOI: 10.1002/jhet.4185
Mehdi Ghandi ₁ , Meysam Khodadadi ₁ , Alireza Abbasi ₁

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A simple, new two‐step procedure for the synthesis of novel tricyclic pyrrolo[2,1‐a]isoquinoline derivatives is described. The initially prepared polysubstituted pyrroles obtained via the four‐component condensation of arylglyoxals, cyclic 1,3‐dicarbonyls, aminoacetaldehyde dimethyl acetal, and β‐keto esters subsequently underwent intramolecular acid‐catalyzed cyclization to the desired products in moderate to good yields.

中文翻译：

组合的多组分酸催化环化反应作为新型三环吡咯并[2,1-a]异喹啉衍生物的有效途径

描述了一种用于合成新型三环吡咯并[2,1– a ]异喹啉衍生物的简单，新的两步程序。最初制备的多取代吡咯是通过芳基乙二醛，环状1,3-二羰基，氨基乙醛二甲基乙缩醛和β-酮酯的四组分缩合反应获得的，随后以中等至良好的收率进行了分子内酸催化的环化反应生成所需的产物。

更新日期：2020-11-17

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