Anticarsia gemmatalis larvae are key defoliating pests of soybean plants. Inorganic insecticides, harmful to the environment and human health, are the main molecules used in the control of this pest. To apply more sustainable management methods, organic molecules with high specificities, such as proteinaceous protease inhibitors, have been sought. Thus, molecular docking studies, kinetics assays, and biological tests were performed to evaluate the inhibitory activity of two peptides (GORE1 and GORE2) rationally designed to inhibit trypsin‐like enzymes, which are the main proteases of A. gemmatalis midgut.

中文翻译：

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小肽可抑制肠胰蛋白酶样蛋白酶并损害双歧抗Anti虫（鳞翅目：夜蛾科）的生存和发育

抗carcarsia gemmatalis幼虫是大豆植物的主要落叶害虫。对环境和人体健康有害的无机杀虫剂是控制该害虫的主要分子。为了应用更可持续的管理方法，已经寻求了具有高特异性的有机分子，例如蛋白质蛋白酶抑制剂。因此，进行了分子对接研究，动力学测定和生物学测试，以评估合理设计为抑制胰蛋白酶样酶（这是双歧杆菌中肠的主要蛋白酶）的两种肽（GORE1和GORE2）的抑制活性。