Metallocene QACs: The Incorporation of Ferrocene Moieties into monoQAC and bisQAC Structures,ChemMedChem

当前位置： X-MOL 学术 › ChemMedChem › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Metallocene QACs: The Incorporation of Ferrocene Moieties into monoQAC and bisQAC Structures
ChemMedChem ( IF 3.6 ) Pub Date : 2020-11-16 , DOI: 10.1002/cmdc.202000605
Kyle J Sommers ₁ , Brian S Bentley ₁ , Robert G Carden ₁ , Savannah J Post ₂ , Ryan A Allen ₂ , Renee C Kontos ₁ , Jacob W Black ₁ , William M Wuest ₂ , Kevin P C Minbiole ₁

Affiliation

Inspired by the incorporation of metallocene functionalities into a variety of bioactive structures, particularly antimicrobial peptides, we endeavored to broaden the structural variety of quaternary ammonium compounds (QACs) by the incorporation of the ferrocene moiety. Accordingly, 23 ferrocene‐containing mono‐ and bisQACs were prepared in high yields and tested for activity against a variety of bacteria, including Gram‐negative strains and a panel of clinically isolated MRSA strains. Ferrocene QACs were shown to be effective antiseptics with some displaying single‐digit micromolar activity against all bacteria tested, demonstrating yet another step in the expansion of structural variety of antiseptic QACs.

中文翻译：

茂金属QAC：将二茂铁部分结合到monoQAC和bisQAC结构中

受到将茂金属官能团结合到各种生物活性结构，特别是抗菌肽中的启发，我们努力通过结合二茂铁部分来拓宽季铵化合物 (QAC) 的结构多样性。因此，以高产率制备了 23 种含二茂铁的单 QAC 和双 QAC，并测试了其对多种细菌的活性，包括革兰氏阴性菌株和一组临床分离的 MRSA 菌株。二茂铁 QAC 被证明是有效的防腐剂，其中一些对所有测试的细菌显示出个位数的微摩尔活性，这表明在扩展防腐 QAC 的结构多样性方面又迈出了一步。

更新日期：2020-11-16

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11