Abnormal tremors are the most common of all movement disorders. In this review we focus on the role of the cerebellum in Essential Tremor, a highly debilitating but poorly treated movement disorder. We propose a variety of mechanisms driving abnormal burst firing of deep cerebellar nuclei neurons as a key initiator of tremorgenesis in Essential Tremor. Targetting these mechanisms may generate more effective treatments for Essential Tremor.

中文翻译：

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原发性震颤-小脑驱动的疾病？

异常震颤是所有运动障碍中最常见的。在这篇综述中，我们关注小脑在原发性震颤中的作用，原发性震颤是一种高度虚弱但治疗不良的运动障碍。我们提出了多种机制来驱动深部小脑核神经元的异常爆发，这是原发性震颤中震颤发生的关键发起者。针对这些机制可能会针对原发性震颤产生更有效的治疗方法。