Manganese-zinc ferrite is a kind of very important magnetic ferrite material. The properties of wide absorption band, sensitivity to ultraviolet (UV) light and tumor H₂O₂ promise it to be possibly used as a photothermal therapy (PTT), photodynamic therapy (PDT) and chemodynamic therapy (CDT) agent. Based on the unique advantages of rare-earth doped nanoparticles, an Er³⁺, Tm³⁺ co-doped upconversion-mediated nanosystem with manganese-zinc ferrite shell (named as UCNPS@M) was developed through a facile thermal co-decomposition method. The final nanosystems were surface-modified by using dopamine hydrochloride (DA) in order to warrant good biocompatibility (named as UCNPS@M@DA). Under irradiation of near-infrared (NIR) light, UCNPS emit both ultraviolet and visible light. The UV light is mostly absorbed by manganese-zinc ferrite shell to produce reactive oxygen species (ROS), which is essential to the potential PDT and CDT effect of nanosystems, and at the same time, Mn_0.5Zn_0.5Fe₂O₄ can further react with H₂O₂ to promote the efficiency of •OH-generation. It is expected that UCNPS@M@DA can act as upconversion luminescence imaging guidance due to the visible emission from UCNPS. In addition, the energy absorbed by the nanosystems can be transferred to heat to realize photothermal effect. Moreover, UCNPS@M@DA was successfully applied as a T₁/T₂-weighted magnetic resonance imaging (MRI) contrast agent due to the existence of Gd, Mn, and Fe elements. In light of the upconversion luminescence (UCL) imaging from the UCNPS as well as potential PTT, PDT, CDT effect mentioned above, this work provides a possibility to realize cancer multi-model bioimaging guided treatment by using an all-in-one diagnosis and therapy nanosystem through a simple yet powerful strategy.

锰锌铁氧体是一种非常重要的磁性铁氧体材料。吸收带宽、对紫外线(UV)光和肿瘤H ₂ O ₂敏感的特性使其有可能用作光热疗法(PTT)、光动力疗法(PDT)和化学动力学疗法(CDT)剂。基于稀土掺杂纳米粒子的独特优势，Er ³⁺、Tm ³⁺通过简便的热共分解方法开发了具有锰-锌铁氧体壳的共掺杂上转换介导的纳米系统（命名为 UCNPS@M）。最终的纳米系统通过使用多巴胺盐酸盐（DA）进行表面改性，以保证良好的生物相容性（命名为 UCNPS@M@DA）。在近红外 (NIR) 光的照射下，UCNPS 发出紫外光和可见光。紫外光主要被锰锌铁氧体壳吸收产生活性氧（ROS），这对纳米系统潜在的 PDT 和 CDT 效应至关重要，同时 Mn _0.5 Zn _0.5 Fe ₂ O ₄可以进一步与 H ₂ O ₂反应提高•OH 生成效率。由于来自 UCNPS 的可见光发射，预计 UCNPS@M@DA 可以作为上转换发光成像引导。此外，纳米系统吸收的能量可以转化为热量，实现光热效应。此外，由于存在 Gd、Mn 和 Fe 元素，UCNPS@M@DA 被成功用作T ₁ / T ₂加权磁共振成像 (MRI) 造影剂。鉴于来自 UCNPS 的上转换发光 (UCL) 成像以及上述潜在的 PTT、PDT、CDT 效应，这项工作为通过使用多合一诊断和治疗实现癌症多模型生物成像引导治疗提供了可能。通过简单而强大的策略治疗纳米系统。