Abstract Organic solvent nanofiltration (OSN), also known as solvent resistant nanofiltration (SRNF), has enormous potential for industrial applications. Among the emerging high-performance membrane materials, some have proven challenging to fabricate ultrathin selective layers and at a scale large enough to be practical for industrial consideration. This work demonstrates a facile and scalable solution casting method to prepare ultrathin composite films from advanced polymeric materials and porous additives. Using this method, poly(trimethylsilylpropyne) (PTMSP) membranes could be controlled to just 250 nm thickness resulting in 2 to 30-fold higher solvent permeance than other PTMSP membranes reported to date. Two highly porous additives, poly-dichloroxylene (p-DCX) and Porous Aromatic Framework (PAF-1) were employed to fabricate ultrathin PTMSP composite membranes. Compared to the native PTMSP membrane (methanol permeance of 11.5 L m−2 h−1 bar−1), these additives enhanced membrane permeance by 75% (20.1 L m−2 h−1 bar−1) and 50% (17.2 L m−2 h−1 bar−1), respectively. Inclusion of the porous additives also enhanced membrane stability, demonstrated by 300 h of continuous OSN operation. These membranes showed improved molecular weight cut-off (MWCO) and significant potential in the separation of active pharmaceutical ingredients (APIs), including the almost complete rejection of Vitamin B12 in methanol. This work demonstrates that the facile production of ultrathin membranes using intrinsically microporous polymers is possible, enabling these exciting membrane materials to be considered for industrial applications.

中文翻译：

---

构建用于高效有机溶剂纳滤 (OSN) 的超薄 PTMSP/多孔纳米添加剂膜

摘要 有机溶剂纳滤（OSN），也称为耐溶剂纳滤（SRNF），具有巨大的工业应用潜力。在新兴的高性能膜材料中，有些材料已被证明难以制造超薄选择性层，而且规模大到足以用于工业考虑。这项工作展示了一种简便且可扩展的溶液浇铸方法，可以用先进的聚合物材料和多孔添加剂制备超薄复合膜。使用这种方法，聚（三甲基甲硅烷基丙炔）（PTMSP）膜可以控制在仅 250 nm 的厚度，导致溶剂渗透性比迄今为止报道的其他 PTMSP 膜高 2 到 30 倍。两种高度多孔的添加剂，聚二氯二甲苯（p-DCX）和多孔芳香骨架（PAF-1）被用来制造超薄PTMSP复合膜。与天然 PTMSP 膜（甲醇渗透率为 11.5 L m-2 h-1 bar-1）相比，这些添加剂将膜渗透率提高了 75%（20.1 L m-2 h-1 bar-1）和 50%（17.2 L分别为 m−2 h−1 bar−1)。包含多孔添加剂还增强了膜的稳定性，这通过 300 小时的连续 OSN 操作得到了证明。这些膜显示出更高的截留分子量 (MWCO) 和在分离活性药物成分 (API) 方面的巨大潜力，包括几乎完全去除甲醇中的维生素 B12。这项工作表明，使用本征微孔聚合物轻松生产超薄膜是可能的，