Understanding the mechanisms that establish regulatory T (Treg) cell identity is central to understanding Treg cell function. van der Veeken et al. now show that the lineage-determining transcription factor Foxp3 establishes Treg-cell-specific chromatin architecture indirectly, mostly by decreasing the expression of other transcriptional regulators, including TCF1.

中文翻译：

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Foxp3重新分配其繁重的工作

了解建立调节性T（Treg）细胞身份的机制是了解Treg细胞功能的关键。van der Veeken等。现在显示，谱系决定转录因子Foxp3间接建立Treg细胞特异性染色质体系，主要是通过降低其他转录调节因子（包括TCF1）的表达。