Allergens induce type-2 immunity, but unresolved questions remain about initiation of this response. In this issue, Perner et al. propose that cutaneous activation of TRPV1⁺ sensory neurons by protease allergens stimulates release of substance P to induce migration of Th2-skewing CD301b⁺ DC to draining lymph nodes.

中文翻译：

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过敏原通过触发开关来启动2型免疫

变应原诱导2型免疫，但是关于此反应的启动仍未解决。在本期中，Perner等人。提出蛋白酶过敏原对TRPV1 ⁺感觉神经元的皮肤活化可刺激P物质的释放，从而诱导Th2倾斜的CD301b ⁺ DC迁移至引流淋巴结。