Pre-existing humoral immunity can impact immune responses to heterologous infections. In this issue of Immunity, Wong et al. reveal that memory B cells, while failing to re-enter the germinal center, create an affinity-restricted, diversified B cell repertoire for rapid plasma blast responses. Their findings have important implications to vaccine design.

中文翻译：

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记忆力下降—赢得慢速比赛

预先存在的体液免疫可以影响对异源感染的免疫反应。在本期《免疫》中，Wong等人。揭示了记忆B细胞虽然无法重新进入生发中心，却产生了亲和力受限的，多样化的B细胞库，可快速进行血浆原始细胞反应。他们的发现对疫苗设计具有重要意义。