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Acute and chronic effects of diazepam on the polychaete Hediste diversicolor: Antioxidant, metabolic, pharmacologic, neurotoxic and behavioural mechanistic traits
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-11-17 , DOI: 10.1016/j.etap.2020.103538
Ana Filipa Nogueira , Bruno Nunes

Pharmaceutical drugs are widespread environmental contaminants, but data about their adverse effects are still limited to a few compounds. This study analyzed the acute (96 h) and chronic (28 days) impacts of environmentally realistic levels of diazepam (acute exposure: 0.001, 0.01, 0.1, 1, 10 μg/L; chronic exposure: 0.1, 1, 10, 100, 1000 ng/L), in the polychaete Hediste diversicolor, by measuring behavioral and biochemical (catalase [CAT], glutathione-S-transferases [GSTs], cholinesterases [ChEs], glutathione peroxidase [GPx], lipid peroxidation [TBARS]) parameters. Acute exposure to diazepam altered behavioral traits, decreasing burrowing times and causing hyperactivity, whilst burrowing time increased and hypoactivity resulted after chronic exposure. All biomarkers were affected after the chronic exposure, with the exception of lipid peroxidation. Our data demonstrate that realistic levels of diazepam may impair behavioral and biochemical traits in polychaetes, suggesting that diazepam exposure presents a significant challenge to the environment that supports these organisms.



中文翻译:

地西epa对多斑杂色蛙的急性和慢性作用:抗氧化,代谢,药理,神经毒性和行为机制性状

药物是广泛的环境污染物,但有关其不良影响的数据仍仅限于少数化合物。这项研究分析了环境实际水平地西epa的急性(96 h)和慢性(28天)影响(急性暴露:0.001、0.01、0.1、1、10μg/ L;慢性暴露:0.1、1、10、100, 1000 ng / L),在多色杂色菊(Hediste diversicolor)中通过测量行为和生化参数(过氧化氢酶[CAT],谷胱甘肽S-转移酶[GST],胆碱酯酶[ChEs],谷胱甘肽过氧化物酶[GPx],脂质过氧化[TBARS])参数。急性暴露于地西exposure会改变行为特征,减少穴居时间并引起多动,而慢性接触后穴居时间会增加,并且会引起机能减退。长期暴露后所有生物标志物均受到影响,脂质过氧化除外。我们的数据表明,地西epa的现实水平可能会损害多毛cha的行为和生化特征,这表明地西epa的暴露对支持这些生物的环境提出了重大挑战。

更新日期:2020-12-01
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