Hyperbranched polymers (HBPs), such as hyperbranched polyglycerols (HPGs) with a dendritic configuration, have been recognized for their excellent biocompatibility and multifunctionalization. HPGs have been studied for use in the delivery diagnostic, imaging and therapeutic molecules in the area of nanobiomedicine. They show superior characteristics to linear polymers and dendrimers, such as compact structure, a simple manufacturing process with easy functionalization ability, low viscosity, and high stability. Owing to these advantages, HPGs are now considered promising carriers for drug delivery, diagnostics, imaging, and theranostics applications for cancer treatment. In this review, we also discuss safety aspects of HPG-based nanoformulations in various animal models and the clinical translation status of such polymers for real-time applications.

超支化聚合物 (HBP)，例如具有树枝状结构的超支化聚甘油 (HPG)，因其出色的生物相容性和多功能化而得到认可。HPG 已被研究用于在纳米生物医学领域中递送诊断、成像和治疗分子。它们表现出优于线性聚合物和树枝状聚合物的特性，例如结构紧凑、制造工艺简单、易于官能化、粘度低和稳定性高。由于这些优势，HPG 现在被认为是用于癌症治疗的药物输送、诊断、成像和治疗诊断学应用的有前途的载体。在本次审查中，