BACKGROUND White matter hyperintensities (WMH) are estimated to occur in greater than 63% of older adults over the age of 60 years. WMH identified in the T2-weighted FLAIR images can be combined with T1-weighted images to enhance individualized current flow models of older adults by accounting for the presence of WMH and its effects on delivered tES current in the aging brain. METHODS Individualized head models were derived from T1-weighted images of 130 healthy older adults (mean=71years). Lesions segmented from FLAIR acquisition were added to individualized models. Current densities were computed in the brain and compared between models with and without lesions. MAIN RESULTS Integrating WMH into the models resulted in an overall decrease (up to 7%) in median current densities in the brain outside lesion regions. Changes in current density and total lesion volume was positively correlated (R2=0.3, p<0.0001). CONCLUSIONS Incorporating WMH into individualized models may increase the accuracy of predicted tES current flow in the aging brain.

中文翻译：

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白质高信号影响老化大脑中的经颅电刺激

背景 估计超过 63% 的 60 岁以上老年人发生白质高信号 (WMH)。在 T2 加权 FLAIR 图像中识别的 WMH 可以与 T1 加权图像相结合，通过考虑 WMH 的存在及其对衰老大脑中传递的 tES 电流的影响来增强老年人的个性化电流模型。方法 个性化头部模型来自 130 名健康老年人（平均 71 岁）的 T1 加权图像。从 FLAIR 获取分割的病变被添加到个性化模型中。在大脑中计算电流密度，并在有和没有病变的模型之间进行比较。主要结果 将 WMH 整合到模型中导致大脑病变区域外的中值电流密度整体下降（高达 7%）。电流密度和总病变体积的变化呈正相关（R2=0.3，p<0.0001）。结论 将 WMH 纳入个性化模型可能会提高预测 tES 电流在老化大脑中的准确性。