Sulfane sulfur species comprise a variety of biologically relevant hydrogen sulfide (H₂S)-derived species, including per- and poly-sulfidated low molecular weight compounds and proteins. A growing body of evidence suggests that H₂S, currently recognized as a key signaling molecule in human physiology and pathophysiology, plays an important role in cancer biology by modulating cell bioenergetics and contributing to metabolic reprogramming. This is accomplished through functional modulation of target proteins via H₂S binding to heme iron centers or H₂S-mediated reversible per- or poly-sulfidation of specific cysteine residues. Since sulfane sulfur species are increasingly viewed not only as a major source of H₂S but also as key mediators of some of the biological effects commonly attributed to H₂S, the multifaceted role of these species in cancer biology is reviewed here with reference to H₂S, focusing on their metabolism, signaling function, impact on cell bioenergetics and anti-tumoral properties.

硫磺类物质包括多种生物相关的硫化氢（H ₂ S）衍生物质，包括全硫化和多硫化的低分子量化合物和蛋白质。越来越多的证据表明，H ₂ S是目前公认的人类生理学和病理生理学中的关键信号分子，它通过调节细胞生物能并促进代谢重编程在癌症生物学中发挥重要作用。这是通过结合H ₂ S与血红素铁中心或H ₂ S介导的特定半胱氨酸残基的可逆过硫酸或多硫化作用对靶蛋白进行功能性调节来实现的。由于硫磺物种越来越多地被视为不仅是H ₂的主要来源秒，但也为一些通常归因于小时生物效应的关键调解人₂ S，在癌症生物学这些物种的多方面的作用是参考与H审查这里₂ S，关注他们的新陈代谢，信号功能，影响细胞生物能量学和抗肿瘤特性。