Abstract

The reaction of unsubstituted acetoacetamide with aromatic aldehydes in ethanol in the presence of piperidine gave 2-aryl-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxamides and 4-aryl-5-acetyl-2-hydroxy-2-methyl-6-oxopiperidine-3-carboxamides. Structures of the obtained compounds were proved using IR, ¹H and ¹³C NMR spectroscopy methods. The synthesized compounds were tested for antimicrobial and analgesic activities.

中文翻译：

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2-芳基-4-羟基-4-甲基-6-氧代环己烷-1,3-二甲酰胺的合成及生物活性

摘要

在哌啶的存在下，未取代的乙酰乙酰胺与芳族醛在乙醇中的反应得到2-芳基-4-羟基-4-甲基-6-氧代环己烷-1,3-二甲酰胺和4-芳基-5-乙酰基-2-羟基- 2-甲基-6-氧代哌啶-3-羧酰胺。使用IR，¹ H和¹³ C NMR光谱法证明了获得的化合物的结构。测试了合成的化合物的抗菌和镇痛活性。