Abstract

A novel series of bis-isoxazole incorporated benzothiazole derivatives has been designed and synthesized. Molecular structures of the compounds have been confirmed by ¹H and ¹³C NMR, and mass spectra. All products have been tested for their in vitro anticancer activity against breast MCF-7 and MDA MB-231, lungs A549, and prostate DU-145 cancer cell lines using the MTT assay and etoposide as a standard drug. Most of the compounds have demonstrated good to moderate activity, and some of those have exhibited more potent activity than etoposide.

中文翻译：

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双异恶唑并苯并噻唑衍生物的设计，合成及抗癌活性

摘要

已经设计并合成了一系列新的双-异恶唑结合的苯并噻唑衍生物。化合物的分子结构已通过¹ H和¹³ C NMR以及质谱证实。使用MTT分析法和依托泊苷作为标准药物，已对所有产品进行了针对乳腺癌MCF-7和MDA MB-231，肺A549和前列腺DU-145癌细胞系的体外抗癌活性测试。大多数化合物已显示出良好至中度的活性，其中一些化合物比依托泊苷具有更强的活性。