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Design, Synthesis, and Anticancer Activity of Bis-isoxazole Incorporated Benzothiazole Derivatives
Russian Journal of General Chemistry ( IF 0.9 ) Pub Date : 2020-11-17 , DOI: 10.1134/s1070363220100229
Purna Koteswara Rao Cherukumalli , Bhaskara Rao Tadiboina , Kali Charan Gulipalli , Srinu Bodige , Kiran Gangarapu , Gattu Sridhar

Abstract

A novel series of bis-isoxazole incorporated benzothiazole derivatives has been designed and synthesized. Molecular structures of the compounds have been confirmed by 1H and 13C NMR, and mass spectra. All products have been tested for their in vitro anticancer activity against breast MCF-7 and MDA MB-231, lungs A549, and prostate DU-145 cancer cell lines using the MTT assay and etoposide as a standard drug. Most of the compounds have demonstrated good to moderate activity, and some of those have exhibited more potent activity than etoposide.



中文翻译:

双异恶唑并苯并噻唑衍生物的设计,合成及抗癌活性

摘要

已经设计并合成了一系列新的双-异恶唑结合的苯并噻唑衍生物。化合物的分子结构已通过1 H和13 C NMR以及质谱证实。使用MTT分析法和依托泊苷作为标准药物,已对所有产品进行了针对乳腺癌MCF-7和MDA MB-231,肺A549和前列腺DU-145癌细胞系的体外抗癌活性测试。大多数化合物已显示出良好至中度的活性,其中一些化合物比依托泊苷具有更强的活性。

更新日期:2020-11-17
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