The Journal of Membrane Biology ( IF 2.3 ) Pub Date : 2020-11-17 , DOI: 10.1007/s00232-020-00154-x Anjali Rajwar 1 , Vinod Morya 1 , Sumit Kharbanda 1 , Dhiraj Bhatia 1, 2
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Abstract
Continuous, dynamic, and controlled membrane remodeling creates flow of information and materials across membranes to sustain life in all biological systems. Multiple nanoscale phenomena of membranes regulate mesoscale processes in cells, which in turn control macro-scale processes in living organisms. Understanding the molecular mechanisms that cells use for membrane homeostasis, i.e., to generate, maintain, and deform the membrane structures has therefore been the mammoth’s task in biology. Using the principles of DNA nanotechnology, researchers can now precisely recapitulate the functional interactions of the biomolecules that can now probe, program, and re-program membrane remodeling and associated phenomena. The molecular mechanisms for membrane dynamics developing in vitro conditions in which the membrane modulating components are precisely organized and modulated by DNA nanoscaffolds are adding new chapters in the field of DNA nanotechnology. In this review, we discuss DNA nanodevices-based membrane remodeling and trafficking machineries and their applications in biological systems.
Graphic Abstract
中文翻译：
用于探测和编程膜组织、动力学和应用的 DNA 纳米装置
摘要
连续、动态和受控的膜重塑产生跨膜的信息和材料流动，以维持所有生物系统的生命。膜的多种纳米级现象调节细胞中的中尺度过程，进而控制生物体中的宏观尺度过程。因此，了解细胞用于膜稳态的分子机制，即产生、维持和变形膜结构一直是生物学中猛犸象的任务。使用 DNA 纳米技术的原理，研究人员现在可以精确地概括生物分子的功能相互作用，这些生物分子现在可以探测、编程和重新编程膜重塑和相关现象。在体外条件下，膜调节成分由 DNA 纳米支架精确组织和调节的膜动力学分子机制正在为 DNA 纳米技术领域增添新的篇章。在这篇综述中，我们讨论了基于 DNA 纳米器件的膜重塑和贩运机制及其在生物系统中的应用。
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