In this research work, Cerium Oxide/Zinc Oxide (CeO₂/ZnO) composite nanorods are fabricated on aluminium foil substrate using microwave assisted hydrothermal technique. Their crystalline and morphological properties were confirmed using X-Ray diffraction technique (XRD) and scanning electron microscopy (SEM). The aim is to estimate the potential purpose for implementing to possible lead sensor and to analyse their anti-cancer properties against HeLa cells for cervical cancer applications. The developed structural CeO₂/ZnO composite and ZnO nanoparticle systems have been evaluated for anti-cancer efficacy against HeLa (cervical cancerous cell line) and normal (VERO-non cancerous) cell lines. Their results reveal that, CeO₂/ZnO composite nanorods have higher cytotoxic behavior than ZnO NPs against HeLa cancer cells. Under optimized conditions, cyclic voltammetry (CV) was used to study the surface area and employed as working electrode to exploit on sensor characteristics towards the Pb ions. The substantial working electrode characteristics were investigated in phosphate buffer solution (PBS pH 7.4) diluted rice water medium using CV towards typical Pb ions detection. Differential pulse voltammetry (DPV) reveals the sensitivity (19.32 µM/mA) with detection limit (LOD) 14.7 nM and compared with previously reported electrodes exhibiting significant electrochemical sensing activity towards Pb ions. Thus the outcomes on structural CeO₂/ZnO composite system can be used as electrochemical lead sensor and cervical cancer diagnosis applications.

Graphic Abstract

中文翻译：

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微波热辅助多孔结构氧化铈/氧化锌设计：制备，对Pb离子的电化学活性，HeLa和VERO细胞系中的抗癌评估

在这项研究工作中，使用微波辅助水热技术在铝箔基板上制备了氧化铈/氧化锌（CeO ₂ / ZnO）复合纳米棒。使用X射线衍射技术（XRD）和扫描电子显微镜（SEM）确认了它们的晶体和形态特性。目的是评估实现可能的铅传感器的潜在目的，并分析其对宫颈癌应用中的HeLa细胞的抗癌特性。已评估了开发的结构CeO ₂ / ZnO复合材料和ZnO纳米粒子系统对HeLa（宫颈癌细胞系）和正常（VERO非癌细胞）系的抗癌功效。他们的结果表明，CeO ₂/ ZnO复合纳米棒比ZnO NPs对HeLa癌细胞具有更高的细胞毒性。在最佳条件下，循环伏安法（CV）用于研究表面积，并用作工作电极，以开发针对Pb离子的传感器特性。使用CV对典型的Pb离子检测，在磷酸盐缓冲液（PBS pH 7.4）稀释的米水介质中研究了基本的工作电极特性。差分脉冲伏安法（DPV）揭示了灵敏度（19.32 µM / mA），检测限（LOD）为14.7 nM，并且与先前报道的对Pb离子表现出显着电化学感应活性的电极相比。因此，结构性CeO ₂的结果/ ZnO复合系统可用作电化学铅传感器和宫颈癌的诊断应用。

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