Profilin 1 is a crucial actin regulator, interacting with monomeric actin and several actin-binding proteins controlling actin polymerization. Recently, it has become evident that this profilin isoform associates with microtubules via formins and interferes with microtubule elongation at the cell periphery. Recruitment of microtubule-associated profilin upon extensive actin polymerizations, for example, at the cell edge, enhances microtubule growth, indicating that profilin contributes to the coordination of actin and microtubule organization. Here, we provide further evidence for the profilin-microtubule connection by demonstrating that it also functions in centrosomes where it impacts on microtubule nucleation.

中文翻译：

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肌动蛋白调节因子 profilin 1 在功能上与哺乳动物中心体相关。

Profilin 1 是一种关键的肌动蛋白调节剂，与单体肌动蛋白和几种控制肌动蛋白聚合的肌动蛋白结合蛋白相互作用。最近，很明显，这种 profilin 异构体通过 formins 与微管结合并干扰细胞外围的微管伸长。在广泛的肌动蛋白聚合后，例如在细胞边缘，微管相关 profilin 的募集促进了微管的生长，表明 profilin 有助于肌动蛋白和微管组织的协调。在这里，我们通过证明它在影响微管成核的中心体中也起作用，为 profilin-微管连接提供了进一步的证据。