Abstract: HIF-1α is an important factor regulating oxygen balance in mammals, and its expression is closely related to various physiological and pathological conditions of the body. Because HIF-1α plays an important role in the occurrence and development of cancer and other diseases, it has become an enduring research hotspot. At the same time, natural medicines and traditional Chinese medicine compounds have amazing curative effects in various diseases related to HIF-1 subtype due to their unique pharmacological effects and more effective ingredients. Therefore, in this article, we first outline the structure of HIF-1α and the regulation related to its expression, then introduce various diseases closely related to HIF-1α, and finally focus on the regulation of natural medicines and compound Chinese medicines through various pathways. This will help us understand HIF-1α systematically, and use HIF-1α as a target to discover more natural medicines and traditional Chinese medicines that can treat related diseases.

Keywords: HIF-1α, disease, natural medicine, traditional Chinese medicine


中文翻译：

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HIF-1α 是草药治疗疾病的潜在分子靶点

摘要：HIF-1α是哺乳动物体内调节氧平衡的重要因子，其表达与机体各种生理病理状况密切相关。由于HIF-1α在癌症等疾病的发生发展中发挥着重要作用，因此成为经久不衰的研究热点。同时，天然药物和中药复方由于其独特的药理作用和更有效的成分，在与HIF-1亚型相关的各种疾病中具有惊人的疗效。因此，在本文中，我们首先概述HIF-1α的结构和与其表达相关的调控，然后介绍与HIF-1α密切相关的各种疾病，最后重点介绍天然药物和复方中药通过各种途径的调控.

关键词： HIF-1α，疾病，天然药物，中药