Background. The systemic immune-inflammation index (SII) has an important role in predicting survival in some solid tumors. However, little information is available concerning the change of the SII (∆SII) in colorectal cancer (CRC) after curative resection. This study was designed to evaluate the role of ∆SII in CRC patients who received surgery. Methods. A total 206 patients were enrolled in this study. Clinicopathologic characteristics and survival were assessed. The relationships between overall survival (OS), disease-free survival (DFS), and ∆SII were analyzed with both univariate Kaplan-Meier and multivariate Cox regression methods. Results. Based on the patient data, the receiver operating characteristic (ROC) optimal cutoff value of ∆SII was 127.7 for OS prediction. The 3-year and 5-year OS rates, respectively, were 60.4% and 36.7% in the high-∆SII group (>127.7) and 87.6% and 79.8% in the low-∆SII group (≤127.7). The 3-year and 5-year DFS rates, respectively, were 54.1% and 34.1% in the high-∆SII group and 80.3% and 78.5% in the low-∆SII group. In the univariate analysis, smoking, pathological stages III-IV, high-middle degree of differentiation, lymphatic invasion, vascular invasion, and the high-ΔSII group were associated with poor OS. Adjuvant therapy, pathological stages III-IV, vascular invasion, and ΔSII were able to predict DFS. Multivariate analysis revealed that pathological stages III-IV (, 95% -0.827, ), vascular invasion (, 95% -3.829, ), and the high-ΔSII group (, 95% -7.350, ) were independent predictors for OS. Adjuvant therapy (, 95% -0.687, ), vascular invasion (, 95% -5.620, ), and the high-ΔSII group (, 95% -8.102, ) were significant prognostic factors for DFS. Conclusions. The present study demonstrated that ∆SII was associated with the clinical outcome in CRC patients undergoing curative resection, supporting the role of ∆SII as a prognostic biomarker.

中文翻译：

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全身免疫炎症指数的变化独立预测结直肠癌患者根治性切除术后的生存

背景。全身免疫炎症指数 (SII) 在预测某些实体瘤的存活率方面具有重要作用。然而，关于根治性切除后结直肠癌 (CRC) 的 SII (ΔSII) 变化的信息很少。本研究旨在评估 ΔSII 在接受手术的 CRC 患者中的作用。方法。共有 206 名患者参加了这项研究。评估临床病理学特征和存活率。使用单变量 Kaplan-Meier 和多变量 Cox 回归方法分析总生存期 (OS)、无病生存期 (DFS) 和 ΔSII 之间的关系。结果. 根据患者数据，对于 OS 预测，ΔSII 的接收者操作特征 (ROC) 最佳截止值为 127.7。高 ΔSII 组 (>127.7) 的 3 年和 5 年 OS 率分别为 60.4% 和 36.7%，低 ΔSII 组 (≤127.7) 分别为 87.6% 和 79.8%。高 ΔSII 组的 3 年和 5 年 DFS 率分别为 54.1% 和 34.1%，低 ΔSII 组分别为 80.3% 和 78.5%。在单因素分析中，吸烟、病理分期 III-IV、高中分化程度、淋巴浸润、血管浸润和高-ΔSII组与较差的 OS 相关。辅助治疗、病理分期 III-IV、血管侵犯和ΔSII能够预测 DFS。多变量分析显示病理阶段 III-IV (, 95%- 0.827,),血管侵犯 (, 95%- 3.829,)和高Δ SII 组 (, 95%- 7.350，)是 OS 的独立预测因子。辅助治疗（, 95%- 0.687,),血管侵犯 (, 95%- 5.620,)和高Δ SII 组 (, 95%- 8.102，)是 DFS 的重要预后因素。结论。本研究表明，ΔSII 与接受根治性切除的 CRC 患者的临床结果相关，支持 ΔSII 作为预后生物标志物的作用。