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Mitochondrial Targeting of Probes and Therapeutics to the Powerhouse of the Cell
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2020-11-15 , DOI: 10.1021/acs.bioconjchem.0c00470
Cindy Ma 1 , Fan Xia 2 , Shana O Kelley 3
Affiliation  

Mitochondria, colloquially known as “the powerhouse of the cell”, play important roles in production, but also in processes critical for cellular fate such as cell death, differentiation, signaling, metabolic homeostasis, and innate immunity. Due to its many functions in the cell, the mitochondria have been linked to a variety of human illnesses such as diabetes, cancer, and neurodegenerative diseases. In order to further our understanding and pharmaceutical targeting of this critical organelle, effective strategies must be employed to breach the complex barriers and microenvironment of mitochondria. Here, we summarize advancements in mitochondria-targeted probes and therapeutics.

中文翻译:

线粒体的探针和治疗靶向细胞的动力。

线粒体通常被称为“细胞的动力源”,在生产中起着重要作用,但在细胞命运至关重要的过程中也起着重要作用,例如细胞死亡,分化,信号传导,代谢稳态和先天免疫。线粒体由于其在细胞中的许多功能,已与多种人类疾病(例如糖尿病,癌症和神经退行性疾病)相关联。为了加深我们对这种关键细胞器的理解和靶向药物,必须采用有效的策略来突破线粒体的复杂障碍和微环境。在这里,我们总结了针对线粒体的探针和治疗方法的进展。
更新日期:2020-12-16
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