Gliomas are a major cause of morbidity. Direct cortical stimulation mapping offers the ability to identify functional areas within the broader neural network both cortically and subcortically. Since the World Health Organization (WHO) 2016 classification categorized gliomas into molecular subgroups with varied molecular signatures and clinical behavior, it is possible that gliomas may demonstrate rates of functional network integration. We therefore retrospectively reviewed a data registry of 181 patients with dominant hemisphere frontal, parietal, insular, or temporal gliomas. Our goal was to test the hypothesis that WHO glioma histopathology and molecular subtype influences functional language or motor sites identified within the tumor. Intratumoral function as determined by direct cortical and subcortical stimulation mapping was identified at the highest rate in isocitrate dehydrogenase mutant astrocytomas and oligodendrogliomas. Finally, we reviewed the emerging literature exploring the interface between functional neural networks and gliomas. These data shed light on glioma molecular and histological characteristics most commonly associated within intratumoral function.

中文翻译：

---

胶质瘤网络接口：胶质瘤分子亚型与瘤内功能关系综述

胶质瘤是发病的主要原因。直接皮质刺激映射提供了在更广泛的神经网络中识别皮质和皮质下功能区域的能力。由于世界卫生组织 (WHO) 2016 年将胶质瘤分类为具有不同分子特征和临床行为的分子亚组，因此胶质瘤可能表现出功能网络整合率。因此，我们回顾性审查了 181 名优势半球额叶、顶叶、岛叶或颞叶胶质瘤患者的数据登记。我们的目标是检验 WHO 胶质瘤组织病理学和分子亚型影响肿瘤内确定的功能性语言或运动部位的假设。在异柠檬酸脱氢酶突变星形细胞瘤和少突胶质细胞瘤中，通过直接皮层和皮层下刺激标测确定的瘤内功能最高。最后，我们回顾了探索功能神经网络和神经胶质瘤之间接口的新兴文献。这些数据揭示了最常与肿瘤内功能相关的神经胶质瘤分子和组织学特征。