Objective:Reading difficulties are one of the most significant challenges for children with neurofibromatosis type 1 (NF1). The aims of this study were to identify and categorize the types of reading impairments experienced by children with NF1 and to establish predictors of poor reading in this population.Method:Children aged 7–12 years with NF1 (n = 60) were compared with typically developing children (n = 36). Poor word readers with NF1 were classified according to impairment type (i.e., phonological, surface, mixed), and their reading subskills were compared. A hierarchical multiple regression was conducted to identify predictors of word reading.Results:Compared to controls, children with NF1 demonstrated significantly poorer literacy abilities. Of the 49 children with NF1 classified as poor readers, 20 (41%) were classified with phonological dyslexia, 24 (49%) with mixed dyslexia, and 5 (10%) fell outside classification categories. Children with mixed dyslexia displayed the most severe reading impairments. Stronger working memory, better receptive language, and fewer inattentive behaviors predicted better word reading skills.Conclusions:The majority of children with NF1 experience deficits in key reading skills which are essential for them to become successful readers. Weaknesses in working memory, receptive language, and attention are associated with reading difficulties in children with NF1.

中文翻译：

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分析 1 型神经纤维瘤病学龄儿童的单词阅读能力

目的：阅读困难是 1 型神经纤维瘤病 (NF1) 儿童面临的最大挑战之一。本研究的目的是识别和分类患有 NF1 的儿童所经历的阅读障碍类型，并确定该人群中阅读障碍的预测因子。方法：患有 NF1 的 7-12 岁儿童（n= 60) 与正常发育的儿童 (n= 36)。根据障碍类型（即语音、表面、混合）对NF1阅读能力差的单词阅读器进行分类，并比较他们的阅读子技能。进行分层多元回归以确定单词阅读的预测因子。结果：与对照组相比，NF1 儿童的识字能力明显较差。在 49 名 NF1 阅读障碍儿童中，20 名 (41%) 被归类为语音阅读障碍，24 名 (49%) 为混合阅读障碍，5 名 (10%) 不属于分类类别。混合性阅读障碍儿童表现出最严重的阅读障碍。更强的工作记忆、更好的接受性语言和更少的注意力不集中行为预示着更好的单词阅读技能。结论：大多数患有 NF1 的儿童在关键阅读技能方面存在缺陷，这对于他们成为成功的阅读者至关重要。工作记忆、接受性语言和注意力的弱点与 NF1 儿童的阅读困难有关。