Generating standard operating procedures (SOPs) for high-risk chemical processes where toxic, pyrophoric, self-reactive, or energetic materials are used is necessary for academic research safety. When such chemicals are used, the highest level of safety must be employed. The SOP development process provides an opportunity to determine what the reaction setup requirements are, identify potentially unsafe conditions, decide how to properly manage unwanted materials, and perform an overall hazard assessment. Here, we provide suggestions for what SOPs should be developed in academic research institutions and an SOP example for the Grignard reaction (Supporting Information). Developing a complete, shareable library of SOPs, covering common experiments to highly complex techniques, is essential. We strongly believe that the use of well-reasoned and well-written SOPs helps ensure that safe laboratory practices are followed and helps enhance the overall safety culture in academic research departments.

中文翻译：

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生成用于学术实验室中危险化学品处理的标准操作程序

对于学术研究安全而言，必须为使用有毒，发火性，自反应性或高能材料的高风险化学过程生成标准操作程序（SOP）。使用此类化学品时，必须采用最高的安全性。SOP开发过程提供了一个机会来确定反应设置要求是什么，识别潜在的不安全条件，决定如何正确管理不需要的材料以及进行总体危害评估。在这里，我们为应该在学术研究机构中开发哪些标准操作程序提供了建议，并提供了格氏反应（支持信息）的标准操作程序示例。开发一个完整的，可共享的SOP库非常重要，它涵盖了常见实验到高度复杂的技术。