Toward Controlled Electrical Stimulation for Wound Healing Based on a Precision Layered Skin Model,ACS Applied Bio Materials

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Toward Controlled Electrical Stimulation for Wound Healing Based on a Precision Layered Skin Model
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-11-16 , DOI: 10.1021/acsabm.0c01190
Menglu Li _{1,

2} , Xiaofeng Wang ₃ , Pandey Rajagopalan _{1,

2} , Liang Zhang _{1,

2} , Shijie Zhan ₄ , Shuyi Huang _{1,

2} , Wei Li _{1,

2} , Xiangyu Zeng _{1,

2} , Qikai Ye _{1,

2} , Yulu Liu _{1,

2} , Kai Zhong _{1,

2} , Jong Min Kim ₄ , Jikui Luo _{1,

2} , Shurong Dong _{1,

2} , Rongcheng Gu ₅ , Xiaozhi Wang _{1,

2} , Wei-Qiang Tan ₃

Affiliation

Bioelectricity performs vital functions in the human body. When skin is damaged, the endogenous electric field will orient toward the center of wounds, guiding the migration of relevant cells and stimulating the secretion of growth factors. A large number of experiments have indicated that external electric stimuli have significant positive influences on wound healing. However, the mechanism of this therapy remains unclear, and the current selection of parameters for electric stimuli tends to be arbitrary or empirical, making it inefficient and ineffective. From the perspective of bioelectricity and electrochemistry, the mechanism of electric stimuli is investigated in detail based on a sectioned multilayer model in this work, and an electric stimuli window is obtained in terms of frequency, duty cycle, voltage, and electric charge and verified experimentally. This model provides general guidance for the optimization of electrical stimuli therapy for wound healing.

中文翻译：

基于精密分层皮肤模型的伤口愈合控制电刺激

生物电在人体中发挥着重要作用。当皮肤受损时，内源电场会朝向伤口中心，引导相关细胞迁移，刺激生长因子分泌。大量实验表明，外部电刺激对伤口愈合有显着的积极影响。然而，这种疗法的机制仍不清楚，目前对电刺激参数的选择往往是武断的或经验主义的，使其效率低下且无效。本工作从生物电和电化学的角度，基于分段多层模型详细研究了电刺激的机理，得到了频率、占空比、电压、和电荷并通过实验验证。该模型为优化用于伤口愈合的电刺激疗法提供了一般指导。

更新日期：2020-12-21

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