SUMMARY Adaptive immune responses in poultry against the invading parasites are complex, involving both specific and non-specific immunity. Attempts in finding new vaccine candidates for Eimeria parasite infection control are continuing, and any promising candidates that have been discovered so far are only effective against homologous infection. Different genes are involved in coccidiosis protection and take part in Eimeria infections. Expression library immunisation (ELI) is a novel method for systematic screening of genomes to identify new vaccine candidates. Some of these antigens have yielded promising results, with rEtIMP-1 and EtIMP1-CD40L reducing oocysts output with 66 and 78%, respectively, in chickens challenged with Eimeria tenella by inducing immune responses. The significance of cytokines in inducing immunity against the invading parasite cannot be ignored, as they provide support to both innate and adaptive immune responses. Adaptive immune responses and genes expressed in response to E. maxima and E. tenella challenges are important. Possible immunogenic vaccine candidates derived from Eimeria antigens have potential for control, diagnosis and treatment strategies for coccidiosis.

中文翻译：

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鸡对艾美球虫和巨型艾美球虫攻击的适应性免疫反应综述

总结 家禽对入侵寄生虫的适应性免疫反应是复杂的，涉及特异性和非特异性免疫。寻找新的艾美球虫感染控制候选疫苗的尝试仍在继续，迄今为止发现的任何有希望的候选疫苗仅对同源感染有效。不同的基因参与球虫病保护并参与艾美球虫感染。表达文库免疫 (ELI) 是一种系统筛选基因组以鉴定新疫苗候选者的新方法。这些抗原中的一些已经产生了有希望的结果，rEtIMP-1 和 EtIMP1-CD40L 通过诱导免疫反应使感染艾美球虫的鸡的卵囊产量分别减少了 66% 和 78%。细胞因子在诱导针对入侵寄生虫的免疫力方面的重要性不容忽视，因为它们为先天性和适应性免疫反应提供支持。适应性免疫反应和响应于巨型大肠杆菌和柔嫩大肠杆菌挑战而表达的基因很重要。来自艾美球虫抗原的可能的免疫原性候选疫苗具有控制、诊断和治疗球虫病策略的潜力。