Abstract

Objectives

Vitiligo is an autoimmune disease, and its pathogenesis involves changes in cytokine levels in the affected patients. Tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, and IL-17 from pro-inflammatory cytokines, IL-37 in a recently detected anti-inflammatory activity. The aim of our study was to determine serum TNF-α, IL-6, IL-17, IL-37 levels in patients with vitiligo to understand their possible roles in the disease etiology and to compare the results with the healthy controls.

Methods

The study included 48 generalized vitiligo patients who were diagnosed with vitiligo, had an increase in the lesions within the last 3 months, and did not receive any systemic or topical treatment during this period; furthermore, 18 healthy controls were included.

Results

Patient group: n = 48, mean age = 30.48 ± 9.86 years; control group: n = 18, mean age = 28.27 ± 9.66 years. Individuals in the patient group had significantly higher serum levels of IL-37(t = 3.90, p < .001), IL-6 (t = 3.39, p < .05), IL-17 (t = 2.08, p < .05), and TNF-α (t = 4.69 p < .001) than in the control group.

Conclusion

The high levels of (pro-anti) inflammatory cytokines in vitiligo patients draw attention to the importance of cytokines in the pathogenesis of the disease.

中文翻译：

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活动性白癜风患者TNF-α、IL-6、IL-17、IL-37细胞因子水平

摘要

目标

白癜风是一种自身免疫性疾病，其发病机制涉及受影响患者细胞因子水平的变化。肿瘤坏死因子-α (TNF-α)、白细胞介素 (IL)-6 和 IL-17 来自促炎细胞因子，IL-37 在最近检测到抗炎活性。我们研究的目的是确定白癜风患者的血清 TNF-α、IL-6、IL-17、IL-37 水平，以了解它们在疾病病因学中的可能作用，并将结果与​​健康对照进行比较。

方法

该研究纳入了48例全身性白癜风患者，他们被诊断为白癜风，最近3个月内皮损增加，在此期间未接受任何全身或局部治疗；此外，还包括 18 名健康对照。

结果

患者组：n  = 48，平均年龄 = 30.48 ± 9.86 岁；对照组：n  = 18，平均年龄 = 28.27 ± 9.66 岁。患者组个体的血清IL-37（t  = 3.90，p < .001）、IL-6（t  = 3.39，p < .05）、IL-17（t  = 2.08，p < .05）水平显着升高。 05) 和 TNF-α ( t  = 4.69 p < .001) 高于对照组。

结论

白癜风患者体内高水平的（促抗）炎性细胞因子引起了人们对细胞因子在疾病发病机制中的重要性的关注。