Abstract

The prevalence of diffuse idiopathic skeletal hyperostosis (DISH) in prostate cancer patients and its relationship with prevalent vertebral fractures (PVF) has not yet been demonstrated. This study aimed to investigate the relationship of DISH, visceral fat accumulation, and other age-related diseases to PVF in elderly men with castration-naïve prostate cancer (CNPC). A total of 134 CNPC patients who were ≥65 years of age without bone metastases were registered in this study. DISH was found in 36.6% (49/134) of the patients in the study population. Patients with DISH were significantly older and had a lower total hip-bone mineral density (BMD) than those without DISH. On the other hand, there were no significant differences in fat distribution, prevalence of hypertension, dyslipidemia, diabetes, fasting plasma glucose (FPG), hemoglobin A1c (HbA1c, prostate-specific antigen (PSA), or lumbar-BMD (L-BMD). A multivariate analysis of age, DISH, body mass index (BMI), visceral fat area (VFA), and total hip-BMD, which were significantly associated with PVF in a univariate analysis, showed that age (OR 1.11; p = .02) and DISH (OR 5.99; p = .0003) were independently associated with PVF. This study suggests that the presence of DISH may not be negligible when assessing the risk of vertebral fracture in prostate cancer patients before treatment.

摘要

前列腺癌患者弥漫性特发性骨肥厚 (DISH) 的患病率及其与普遍椎骨骨折 (PVF) 的关系尚未得到证实。本研究旨在探讨 DISH、内脏脂肪堆积和其他年龄相关疾病与未去势前列腺癌 (CNPC) 老年男性 PVF 的关系。本研究共纳入134例≥65岁无骨转移的CNPC患者。在研究人群中 36.6% (49/134) 的患者中发现了 DISH。与没有 DISH 的患者相比，患有 DISH 的患者明显年龄更大，髋骨总矿物质密度 (BMD) 更低。另一方面，脂肪分布、高血压患病率、血脂异常、糖尿病、空腹血糖（FPG）、血红蛋白 A1c（HbA1c、前列腺特异性抗原 (PSA) 或腰椎 BMD (L-BMD)。对年龄、DISH、体重指数 (BMI)、内脏脂肪面积 (VFA) 和总髋骨 BMD（在单变量分析中与 PVF 显着相关）的多变量分析表明，年龄（OR 1.11；p  = .02）和 DISH（OR 5.99；p  = .0003）与 PVF 独立相关。这项研究表明，在评估前列腺癌患者治疗前椎体骨折的风险时，DISH 的存在可能不容忽视。