ABSTRACT

Introduction: We present our views on the current application of mass spectrometry (MS) based lipidomics and how lipidomics can develop in the next decade to be most practical use to society. That is not to say that lipidomics has not already been of value. In-fact, in its earlier guise as metabolite profiling most of the pathways of steroid biosynthesis were uncovered and via focused lipidomics many inborn errors of metabolism are routinely clinically identified. However, can lipidomics be extended to improve biochemical understanding of, and to diagnose, the most prevalent diseases of the 21^st century?

Areas covered: We will highlight the concept of ‘level of identification’ and the equally crucial topic of ‘quantification’. Only by using a standardized language for these terms can lipidomics be translated to fields beyond academia. We will remind the lipid scientist of the value of chemical derivatization, a concept exploited since the dawn of lipid biochemistry.

Expert opinion: Only by agreement of the concepts of identification and quantification and their incorporation in lipidomics reporting can lipidomics maximize its value.

摘要

简介：我们介绍了我们对当前基于质谱 (MS) 的脂质组学应用的看法，以及脂质组学如何在未来十年发展成为最实用的社会用途。这并不是说脂质组学还没有价值。事实上，在其早期的代谢物分析中，类固醇生物合成的大部分途径都被发现了，并且通过重点脂质组学，许多先天性代谢错误在临床上得到了常规鉴定。然而，脂类组学可以扩展到提高的生化理解和诊断，21个最普遍的疾病^ST世纪？

涵盖的领域：我们将强调“识别水平”的概念和同样重要的“量化”主题。只有对这些术语使用标准化的语言，脂质组学才能被翻译到学术界以外的领域。我们将提醒脂质科学家化学衍生化的价值，这是自脂质生物化学诞生以来就被利用的概念。

专家意见：只有在鉴定和量化的概念上达成一致并将其纳入脂质组学报告中，脂质组学才能最大限度地发挥其价值。