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Disorders of sleep and wakefulness in amyotrophic lateral sclerosis (ALS): a systematic review
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration ( IF 2.5 ) Pub Date : 2020-11-16 , DOI: 10.1080/21678421.2020.1844755
Diana Lucia 1 , Pamela A McCombe 2, 3 , Robert D Henderson 2, 3 , Shyuan T Ngo 1, 2, 3
Affiliation  

Abstract

Disorders of sleep and wakefulness are common among neurodegenerative diseases. While amyotrophic lateral sclerosis (ALS) predominately manifests as motor symptoms, there is emerging evidence that disruptions to sleep and wakefulness also occur. This systematic review aims to report the most common disorders of sleep and wakefulness in ALS. We conducted a qualitative systematic review as per PRISMA guidelines and searched literature assessing the association between disorders of sleep and wakefulness with ALS using the PubMed and Medline database. Overall, 50–63% of patients with ALS have poor sleep quality as reported using the Pittsburgh Sleep Quality Index Questionnaire (PSQI). A higher proportion of ALS patients are categorized as poor sleepers, however there is conflicting evidence as to whether patients with ALS are more likely to exhibit excessive daytime sleepiness. Of the studies that utilized polysomnography, all reported various degrees of impairment to sleep microstructure and architecture among ALS patients. In future, longitudinal clinical studies will be essential for establishing the significance of impaired sleep in ALS. Future studies are also needed to establish whether the self-reported measures of poor sleep and impairment to sleep architecture occurs as a direct consequence of the disease, whether they are an early manifestation of the disease, and/or if they contribute to the neurodegenerative process.



中文翻译:

肌萎缩侧索硬化症(ALS)的睡眠和觉醒障碍:系统评价

摘要

睡眠和觉醒障碍在神经退行性疾病中很常见。虽然肌萎缩侧索硬化 (ALS) 主要表现为运动症状,但有新的证据表明睡眠和觉醒也会受到干扰。本系统评价旨在报告 ALS 中最常见的睡眠和觉醒障碍。我们根据 PRISMA 指南进行了定性系统评价,并使用 PubMed 和 Medline 数据库检索了评估睡眠障碍和清醒与 ALS 之间关联的文献。总体而言,根据匹兹堡睡眠质量指数问卷 (PSQI) 的报告,50-63% 的 ALS 患者睡眠质量较差。较高比例的 ALS 患者被归类为睡眠不佳者,然而,关于 ALS 患者是否更可能表现出过度的白天嗜睡,存在相互矛盾的证据。在使用多导睡眠图的研究中,所有研究都报告了 ALS 患者睡眠微观结构和结构的不同程度的损害。将来,纵向临床研究对于确定 ALS 睡眠受损的重要性至关重要。未来的研究还需要确定自我报告的睡眠不佳和睡眠结构受损的措施是否是疾病的直接后果,它们是否是疾病的早期表现,和/或它们是否有助于神经退行性过程. 都报告了 ALS 患者睡眠微观结构和结构的不同程度的损害。将来,纵向临床研究对于确定 ALS 睡眠受损的重要性至关重要。未来的研究还需要确定自我报告的睡眠不佳和睡眠结构受损的措施是否是疾病的直接后果,它们是否是疾病的早期表现,和/或它们是否有助于神经退行性过程. 都报告了 ALS 患者睡眠微观结构和结构的不同程度的损害。将来,纵向临床研究对于确定 ALS 睡眠受损的重要性至关重要。未来的研究还需要确定自我报告的睡眠不佳和睡眠结构受损的措施是否是疾病的直接后果,它们是否是疾病的早期表现,和/或它们是否有助于神经退行性过程.

更新日期:2020-11-16
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