AgI‐promoted one‐pot synthesis of aminoindolizines via sequential Mannich‐Grignard addition and intramolecular cyclization in water,Journal of Heterocyclic Chemistry

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AgI‐promoted one‐pot synthesis of aminoindolizines via sequential Mannich‐Grignard addition and intramolecular cyclization in water
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-11-16 , DOI: 10.1002/jhet.4184
Veeranna Guguloth ₁ , Ramesh Balaboina ₁ , Suresh Paidakula ₁ , Narasimha S. Thirukovela ₂ , Ravinder Vadde ₁

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The efficient synthesis of aminoindolizines in ecofriendly water with broad substrate scope from the mild and readily available AgI‐catalyzed one‐pot three‐component reaction of pyridine‐2‐carboxaldehyde, secondary amines, and terminal alkynes proceeds through the sequential Mannich‐Grignard addition as well as intramolecular cyclization was reported for the first time.

中文翻译：

AgI促进Mannich-Grignard的顺序添加和水中分子内环化作用的一锅合成氨基吲哚嗪

氨基-2-吲哚嗪类化合物在环保的水中有效合成，其底物范围广泛，这是通过温和且易于获得的AgI催化的吡啶-2-羧醛，仲胺和末端炔烃的一锅三组分反应，通过依次添加曼尼希-格里雅纳（Mannich-Grignard）进行的。首次报道了分子内环化。

更新日期：2020-11-16

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