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Microfluidic Whispering Gallery Mode Optical Sensors for Biological Applications
Laser & Photonics Reviews ( IF 9.8 ) Pub Date : 2020-11-16 , DOI: 10.1002/lpor.202000135 Yuye Wang 1, 2 , Shuwen Zeng 2, 3 , Georges Humbert 2 , Ho‐Pui Ho 1
Laser & Photonics Reviews ( IF 9.8 ) Pub Date : 2020-11-16 , DOI: 10.1002/lpor.202000135 Yuye Wang 1, 2 , Shuwen Zeng 2, 3 , Georges Humbert 2 , Ho‐Pui Ho 1
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Whispering gallery mode (WGM) resonators have been exploited as a highly sensitive and efficient sensing technique in the past few years. They offer the advantages of ultrahigh sensitivity, compact size, and label‐free sensing capability. More recently, with the rapid development of microfluidic technologies, many integrated WGM sensors, by combining the portability of lab‐on‐chip devices and the high sensitivity of WGM resonators, have emerged. The capabilities of efficient sample handling and multiplexed analyte detection offered by these systems have led to many biological and chemical sensing applications, especially for the detection of single particle or biomolecule. In this review, different sensing mechanisms based on integrated whispering gallery mode resonators are introduced. Various geometries of WGM cavities including solid, liquid, and hollow resonators and a detailed discussion on their integration with microfluidic devices are also covered. Different types of packaging schemes and integration methods are compared in terms of ease of fabrication and device performance. Finally, recent applications of microfluidic‐based WGM sensors for detecting biological and chemical target molecules are discussed, with a prospect on future challenges and trends of development in microfluidics for multiplexed detection.
中文翻译：
用于生物应用的微流体回音壁模式光学传感器
在过去的几年中，回音壁模式（WGM）谐振器已被用作一种高度灵敏，高效的传感技术。它们具有超高灵敏度，紧凑尺寸和无标签感应功能的优点。最近，随着微流体技术的飞速发展，结合了芯片实验室设备的便携性和WGM谐振器的高灵敏度，出现了许多集成的WGM传感器。这些系统提供的高效样品处理和多重分析物检测功能已导致许多生物和化学传感应用，尤其是用于检测单个颗粒或生物分子。在这篇综述中，介绍了基于集成式回音壁模式谐振器的不同传感机制。WGM腔的各种几何形状，包括固体，液体，空心谐振器及其与微流控器件集成的详细讨论也包括在内。比较了不同类型的封装方案和集成方法，以简化制造和设备性能。最后，讨论了基于微流体的WGM传感器在检测生物和化学目标分子中的最新应用，并展望了用于多重检测的微流体技术的未来挑战和发展趋势。
更新日期：2020-12-12
中文翻译：
用于生物应用的微流体回音壁模式光学传感器
在过去的几年中，回音壁模式（WGM）谐振器已被用作一种高度灵敏，高效的传感技术。它们具有超高灵敏度，紧凑尺寸和无标签感应功能的优点。最近，随着微流体技术的飞速发展，结合了芯片实验室设备的便携性和WGM谐振器的高灵敏度，出现了许多集成的WGM传感器。这些系统提供的高效样品处理和多重分析物检测功能已导致许多生物和化学传感应用，尤其是用于检测单个颗粒或生物分子。在这篇综述中，介绍了基于集成式回音壁模式谐振器的不同传感机制。WGM腔的各种几何形状，包括固体，液体，空心谐振器及其与微流控器件集成的详细讨论也包括在内。比较了不同类型的封装方案和集成方法，以简化制造和设备性能。最后，讨论了基于微流体的WGM传感器在检测生物和化学目标分子中的最新应用，并展望了用于多重检测的微流体技术的未来挑战和发展趋势。
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