Tumor infiltrating macrophage are acting on the tumor and the tumor microenvironment in either fighting or supporting tumor development. These modes of action are orchestrated by different signaling molecules as purines and purinergic receptors as excellently review by Arnaud‐Sampaio and colleagues and induce two different flavors of macrophages of the M1 or the M2 type (read more here: 1109‐1126)

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卷97A，第11号，2020年11月封面图像

肿瘤浸润巨噬细胞在对抗或支持肿瘤发展中作用于肿瘤和肿瘤微环境。这些作用方式是由不同的信号分子（如嘌呤和嘌呤能受体）精心编排的，Arnaud-Sampaio及其同事对此进行了出色的综述，并诱导了M1或M2型巨噬细胞的两种不同风味（更多信息请参见此处：1091-1126）