The green alga Haematococcus pluvialis JNU35 is enriched in astaxanthin, linoleic acid and linolenic acid. H. pluvialis JNU35 can be used as an immunostimulant in aquatic feed. Here, the role of H. pluvialis JNU35 in mediating growth, antioxidation, immunity and liver function of Trachinotus ovatus was examined through feeding test. HP0, HP1 and HP5 diets containing 0, 10 and 50 g/kg H. pluvialis JNU35 were prepared for 6‐week feeding. It is shown that the supplement of H. pluvialis JNU35 in diet significantly triggers fish growth through elevating activities of digestive enzymes, food intaking, villus length and upregulating growth hormone and insulin‐like growth factor. H. pluvialis JNU35 supplementation protected from oxidative stress through the Nrf2‐ARE pathway and thus elevated activities of antioxidant enzymes. Meanwhile, H. pluvialis JNU35 supplementation protected liver function by declining lipid deposition, inhibiting hepatocyte apoptosis, upregulating anti‐inflammatory cytokines and downregulating pro‐inflammatory cytokines. Non‐specific immune ability of fish was also promoted by regulating expressions of complement 4, c‐type lysozyme and heat shock protein 70 in HP1 and HP5 diets. The blood health state of fish was improved by H. pluvialis JNU35 supplementation. In conclusion, H. pluvialis JNU35 promoted growth, antioxidation, immunity and liver function in T. ovatus.

中文翻译：

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新分离出的嗜血红球菌JNU35菌株可改善金po（Trachinotus ovatus）的生长，抗氧化，免疫和肝功能

绿藻雨生红球菌JNU35富含虾青素，亚油酸和亚麻酸。H.生红球藻JNU35可以用作在水产饲料免疫刺激剂。在这里，角色H.生红球藻JNU35是在调节生长，抗氧化，免疫和肝功能卵形鲳鲹通过饲养试验研究。含有0,10和50 HP0，HP1和HP5饮食克/千克H.生红球藻JNU35分别为6周馈送制备。它表明，补充H.生红球藻JNU35在通过饮食消化酶的活性升高，食物摄入，绒毛长度和上调生长激素和胰岛素样生长因子显著引发鱼类生长。H.生红球藻JNU35补充通过的Nrf2-ARE途径免受氧化应激和抗氧化酶从而升高活动。同时，H.生红球藻JNU35补充保护肝功能下降的脂质沉积，抑制肝细胞凋亡，上调抗炎细胞因子和下调促炎细胞因子。通过调节HP1和HP5日粮中补体4，c型溶菌酶和热休克蛋白70的表达，还可以提高鱼类的非特异性免疫能力。补充H. pluvialis JNU35可改善鱼的血液健康状况。总之，H.生红球藻JNU35促进生长，抗氧化，免疫和肝功能T.卵形。