Digitally Fabricated and Naturally Augmented In Vitro Tissues,Advanced Healthcare Materials

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Digitally Fabricated and Naturally Augmented In Vitro Tissues
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-11-16 , DOI: 10.1002/adhm.202001253
Daniela F. Duarte Campos ₁ , Laura De Laporte _{1,

2,

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Affiliation

Human in vitro tissues are extracorporeal 3D cultures of human cells embedded in biomaterials, commonly hydrogels, which recapitulate the heterogeneous, multiscale, and architectural environment of the human body. Contemporary strategies used in 3D tissue and organ engineering integrate the use of automated digital manufacturing methods, such as 3D printing, bioprinting, and biofabrication. Human tissues and organs, and their intra‐ and interphysiological interplay, are particularly intricate. For this reason, attentiveness is rising to intersect materials science, medicine, and biology with arts and informatics. This report presents advances in computational modeling of bioink polymerization and its compatibility with bioprinting, the use of digital design and fabrication in the development of fluidic culture devices, and the employment of generative algorithms for modeling the natural and biological augmentation of in vitro tissues. As a future direction, the use of serially linked in vitro tissues as human body‐mimicking systems and their application in drug pharmacokinetics and metabolism, disease modeling, and diagnostics are discussed.

中文翻译：

数字化和自然增强的体外组织

人体体外组织是嵌入生物材料（通常是水凝胶）中的人体细胞的体外3D培养物，可概括人体的异质，多尺度和建筑环境。3D组织和器官工程中使用的当代策略整合了自动化数字制造方法的使用，例如3D打印，生物打印和生物制造。人体组织和器官及其内部和生理间的相互作用特别复杂。由于这个原因，注意力越来越强，将材料科学，医学和生物学与艺术和信息学相交。本报告介绍了生物墨水聚合的计算模型及其与生物印刷的兼容性，在流体培养装置的开发中数字设计和制造的使用，以及使用生成算法对体外组织的自然和生物学扩增进行建模。作为未来的方向，讨论了将串行连接的体外组织用作人体模拟系统及其在药物药代动力学和代谢，疾病建模和诊断中的应用。

更新日期：2021-01-20

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