Chikungunya virus (CHIKV) is an arthropod-borne virus that has re-emerged recently and has spread to previously unaffected regions, resulting in millions of infections worldwide. The genus Alphavirus, in the family Togaviridae, contains several members with a similar potential for epidemic emergence. In order for CHIKV to replicate in targeted cell types it is essential for the virus to enter these cells. In this review, we summarize our current understanding of the versatile and promiscuous steps in CHIKV binding and entry into human and mosquito host cells. We describe the different entry pathways, receptors, and attachment factors so far described for CHIKV and other mosquito-borne alphaviruses and discuss them in the context of tissue tropism and potential therapeutic targeting.

基孔肯雅病毒 (CHIKV) 是一种节肢动物传播的病毒，最近重新出现并传播到以前未受影响的地区，导致全球数百万人感染。披膜病毒科中的甲病毒属包含几个具有类似流行病出现潜力的成员。为了让 CHIKV 在目标细胞类型中复制，病毒必须进入这些细胞。在这篇综述中，我们总结了我们目前对 CHIKV 结合和进入人类和蚊子宿主细胞的多功能和混杂步骤的理解。我们描述了迄今为止为 CHIKV 和其他蚊媒甲病毒描述的不同进入途径、受体和附着因子，并在组织嗜性和潜在治疗靶向的背景下讨论它们。