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Biocompatible and Fluorescent Water Based NIR Emitting CdTe Quantum Dot Probes for Biomedical Applications
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy ( IF 4.3 ) Pub Date : 2020-11-16 , DOI: 10.1016/j.saa.2020.119206
Asha Kumari , Arun Sharma , Rahul Sharma , Udayabanu Malairaman , Ragini Raj Singh

Proficient fluorescent-characteristics, cytotoxicity-behavior and antimicrobial-activity of near-infrared-emitting (NIR) CdTe quantum dots (QDs) were studied sumptuously as these QDs are having an excellence in deep-tissue dissemination of light. These, NIR-emitting QDs were synthesized using aqueous method, utilizing 3-mercaptopropionic-acid (3-MPA) as a stabilizer; it controls leakage of Cd and Te ions from CdTe QDs. However, encapsulation by polymers also prevents the same by seizing toxic consequence of prepared QDs which was confirmed from cytotoxicity studies. Therefore, easy modification according to biological environment of these encapsulated CdTe QDs can serve in bio imaging and distribution. Antimicrobial study investigated the toxic effects of QDs against bacterial strains and support cytotoxicity studies and showing maximum 26 mm zone of inhibition against bacterial strain. These, NIR fluorescent QDs possess many attractive optical properties over the standard fluorescent probes (organic dyes) and can replace these dyes, as there is no specific dye which works in NIR range.



中文翻译:

生物相容性和荧光水基近红外发射CdTe量子点探针,用于生物医学应用

由于这些QD在深层组织光的传播中具有卓越的表现,因此对它们的近乎完美的荧光特性,细胞毒性行为和抗菌活性进行了深入研究。使用3-巯基丙酸(3-MPA)作为稳定剂,通过水相法合成这些发射NIR的量子点。它可以控制CdTe QD中Cd和Te离子的泄漏。但是,通过细胞包封研究也证实了聚合物的包封作用,因为它抓住了制备好的QD的毒性结果,从而防止了这种情况。因此,根据这些封装的CdTe QD的生物学环境进行的轻松修饰可用于生物成像和分布。抗菌研究调查了量子点对细菌菌株的毒性作用,并支持细胞毒性研究,并显示了最大26 mm的细菌菌株抑制区。与标准荧光探针(有机染料)相比,这些NIR荧光QD具有许多吸引人的光学特性,并且可以替代这些染料,因为没有在NIR范围内起作用的特定染料。

更新日期:2020-11-16
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