A link between Covid-19 and development of autoimmunity has been reported. A possible explanation could be molecular mimicry between SARS-CoV-2 and human proteins. Peptide sharing has been found between antigenic epitopes of this virus and heat shock proteins (Hsp) 60 and 90, both of which are associated with autoimmune diseases including those of the bullous type. In particular, there is evidence for the latter Hsp acting as a pathophysiological factor and treatment target in autoimmune blistering dermatoses. Considering multimodal anti-inflammatory mechanisms of action of anti-Hsp90 treatment and drug repositioning results, it may be hypothesized that Hsp90 inhibition could also be a treatment option for cytokine storm-mediated acute respiratory distress syndrome in Covid-19 patients. Hence, although Covid-19-induced autoimmune bullous diseases have not been described in the literature so far, the potential relationship between Covid-19, Hsp, and these autoimmune disorders deserves further attention with respect to both pathophysiology and treatment.

据报道，Covid-19 与自身免疫发展之间存在联系。一种可能的解释是 SARS-CoV-2 和人类蛋白质之间的分子模拟。在该病毒的抗原表位与热休克蛋白 (Hsp) 60 和 90 之间发现了肽共享，这两者都与自身免疫性疾病（包括大疱型疾病）相关。特别是，有证据表明后一种热休克蛋白可作为自身免疫性起泡性皮肤病的病理生理学因素和治疗靶点。考虑到抗 Hsp90 治疗的多模式抗炎作用机制和药物重新定位结果，可以假设 Hsp90 抑制也可能成为 Covid-19 患者细胞因子风暴介导的急性呼吸窘迫综合征的治疗选择。因此，尽管迄今为止文献中尚未描述Covid-19诱发的自身免疫性大疱性疾病，但Covid-19、Hsp和这些自身免疫性疾病之间的潜在关系值得在病理生理学和治疗方面得到进一步关注。