22q11.2 deletion syndrome (22q11DS) is a genetic disorder associated with an increased risk of psychiatric disorders. Vulnerability for psychopathology has been related to an increased reactivity to stress. Here, we examined affective states, perceived stress, affective and psychotic reactivity to various sources of environmental stress using the experience sampling method (ESM), a structured diary technique allowing repeated assessments in the context of daily life. Adults with 22q11DS (n = 31; age, 34.1 years) and matched healthy controls (HCs; n = 24; age, 39.9 years) were included. ESM was used to assess affective states, perceived stress, and stress reactivity. Data were analyzed using multilevel regression models. Adults with 22q11DS displayed overall higher levels of negative affect but comparable levels of positive affect compared to HCs. Higher levels of perceived stress were reported by individuals with 22q11DS. Comparable affective and psychotic reactivity in relation to all types of environmental stress was observed between the two groups. The results point toward higher levels of negative affect and differences in the perception of daily hassles in 22q11DS but no difference in affective or psychotic reactivity to stress. This study contributes to the growing literature regarding the impact of stress on the development of psychopathology in the 22q11DS population.

中文翻译：

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成人 22q11DS 对日常生活压力的情感和精神反应：使用经验抽样方法的研究

22q11.2 缺失综合征 (22q11DS) 是一种与精神疾病风险增加相关的遗传疾病。精神病理学的脆弱性与对压力的反应性增加有关。在这里，我们使用经验抽样法 (ESM) 检查了情感状态、感知压力、情感和心理反应对各种环境压力来源的反应，ESM 是一种结构化日记技术，允许在日常生活中重复评估。包括 22q11DS 成人（n = 31；年龄，34.1 岁）和匹配的健康对照（HC；n = 24；年龄，39.9 岁）。ESM 用于评估情感状态、感知压力和压力反应。使用多级回归模型分析数据。与 HC 相比，患有 22q11DS 的成年人总体上表现出更高水平的负面影响，但具有可比水平的积极影响。22q11DS 患者报告的感知压力水平更高。在两组之间观察到与所有类型的环境压力相关的可比较的情感和精神反应。结果表明，在 22q11DS 中，负面影响水平更高，对日常麻烦的感知存在差异，但对压力的情感或精神反应没有差异。这项研究有助于越来越多的关于压力对 22q11DS 人群精神病理学发展的影响的文献。结果表明，在 22q11DS 中，负面影响水平更高，对日常麻烦的感知存在差异，但对压力的情感或精神反应没有差异。这项研究有助于越来越多的关于压力对 22q11DS 人群精神病理学发展的影响的文献。结果表明，在 22q11DS 中，负面影响水平更高，对日常麻烦的感知存在差异，但对压力的情感或精神反应没有差异。这项研究有助于越来越多的关于压力对 22q11DS 人群精神病理学发展的影响的文献。