Background Intrauterine growth restriction (IUGR) and low birth weight (LBW) have been widely reported as an independent risk factor for hypercholesterolemia and increased hepatic cholesterol underlying liver dysfunction in adulthood. However, the specific impact of uteroplacental insufficiency (UPI), a leading cause of LBW in developed world, on hepatic cholesterol metabolism in later life, is ill defined and is clinically relevant in understanding later life liver metabolic health trajectories.

中文翻译：

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年轻的子宫胎盘功能不全引起的低出生体重成年豚鼠后代肝胆固醇代谢的性别特异性变化

背景技术宫内生长受限（IUGR）和低出生体重（LBW）已被广泛报道为高胆固醇血症和成年肝功能障碍引起的肝胆固醇升高的独立危险因素。然而，子宫胎盘功能不全（UPI）（发达国家中LBW的主要原因）对晚年肝胆固醇代谢的具体影响尚不明确，并且在理解晚年肝代谢健康轨迹方面具有临床意义。